Waxyaalaha la isku qurxiyo iyoMidabkaDheef-shiid kiimikaad
Anabolism Melanin waxaa loo qaybiyaa xilliyo kala duwan. Saynis yahanadu waxay aaminsan yihiin in ay suurtogal tahay in la barto wakiilada caddeynta oo ay ka shaqeeyaan waqtiyo kala duwan oo dheef-shiid kiimikaad ah.
(1) Marxaladda hore ee isku dhafka melanin
① Faragelinta qoraalka iyo/ama glycosylation of tyrosinase; ② Joojinta xakamaynta samaynta tyrosinase; ③ Kontoroolka qoraalka ka dib ee tyrosinase.
(2) muddada synthesis melanin
Sida enzyme muhiimka ah iyo heerka xaddidaadda enzyme ee isku-dhafka melanin, tyrosinase inhibitors waa jihada ugu weyn ee cilmi-baarista iyo horumarinta hadda. Maaddaama inta badan wakiilada caddeynta sida phenol iyo catechol derivatives ay qaab dhismeed la mid yihiin tyrosine iyo dopa, wakiilada caddeynta ee la baaray ayaa inta badan loo kala saaraa inay yihiin kuwa aan tartan ahayn ama tartanka tartanka ee tyrosinase.
(3) Marxaladda dambe ee isku dhafka melanin
①Waxay joojisaa wareejinta melanosome; walxaha leh saamaynta serine protease inhibitory, sida rwj-50353, si buuxda uga fogaadaan midabaynta epidermal ee UBV-sababtay; Soybean trypsin inhibitor waxay leedahay saameyn cad oo cad laakiin wax saameyn ah kuma laha sunta unugyada midabka; Niacinamide, waxay hor istaagi kartaa gudbinta melanocytes ee u dhaxaysa melanocytes iyo keratinocytes; ② Kala firdhinta melanin iyo dheef-shiid kiimikaadka, α-hydroxy acid, aashitada dufanka leh ee bilaashka ah iyo retinoic acid, waxay kiciyaan cusboonaysiinta unugyada waxayna kor u qaadaan melaninized keratinocytes ee saarista.
Waxaa xusid mudan in cilmi-baarista iyo codsiga walxaha caddeynta ee ku salaysan dheef-shiid kiimikaadka sare ee melanin aysan ku habboonayn ka hortagga iyo daaweynta xuubka waayeelka. Maaddaama habka samaynta xuubka seniile uu la xiriiro samaynta lipofuscin, walxaha firfircoon ee antioxidative ayaa caadi ahaan loo isticmaalaa dib u dhigista iyo dib u celinta xuubka waayeelka.
Waqtiga boostada: Jul-29-2022
